Enza Lacivita Selected Research

N- (4- cyanophenylmethyl)- 4- (2- diphenyl)- 1- piperazinehexanamide

10/2017	The brain-penetrant 5-HT7 receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain.
7/2017	Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome.
1/2015	Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.
1/2014	Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats.

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Enza Lacivita Research Topics

Disease

8	Neuroinflammatory Diseases 01/2022 - 07/2016
5	Inflammation (Inflammations) 01/2022 - 11/2017
5	Fragile X Syndrome (Martin Bell Syndrome) 05/2021 - 12/2012
4	Neoplasms (Cancer) 06/2021 - 04/2014
4	Rett Syndrome (Rett's Disorder) 01/2021 - 10/2014
3	Autism Spectrum Disorder 02/2022 - 11/2017
3	Central Nervous System Diseases (CNS Diseases) 01/2022 - 02/2011
2	Alzheimer Disease (Alzheimer's Disease) 12/2021 - 07/2016
2	Neurodevelopmental Disorders 08/2020 - 07/2017
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2019 - 07/2017
2	Sleep Wake Disorders 11/2015 - 01/2014
2	Hyperalgesia 01/2014 - 11/2011
1	Psychotic Disorders (Schizoaffective Disorder) 02/2022
1	Autistic Disorder (Autism) 01/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022
1	Intellectual Disability (Idiocy) 01/2021
1	Neuroblastoma 12/2020
1	Rare Diseases (Rare Disease) 08/2020
1	CDKL5 deficiency disorder 01/2019
1	Schizophrenia (Dementia Praecox) 10/2018
1	Neurogenic Inflammation 01/2018
1	Neuralgia (Stump Neuralgia) 10/2017
1	Prostatic Neoplasms (Prostate Cancer) 01/2017
1	Facial Pain (Myofacial Pain) 05/2016
1	Cognitive Dysfunction 02/2016
1	Hypotension (Low Blood Pressure) 04/2015
1	Lung Neoplasms (Lung Cancer) 02/2015
1	Depressive Disorder (Melancholia) 07/2014
1	Breast Neoplasms (Breast Cancer) 04/2014
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2014
1	Mood Disorders (Mood Disorder) 10/2013
1	Migraine Disorders (Migraine) 11/2011

Drug/Important Bio-Agent (IBA)

12	Serotonin (5 Hydroxytryptamine)IBA 02/2022 - 02/2011
10	serotonin 7 receptorIBA 02/2022 - 02/2011
8	Serotonin ReceptorsIBA 01/2021 - 12/2012
6	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 01/2022 - 07/2016
6	LigandsIBA 01/2022 - 04/2014
5	Peptides (Polypeptides)IBA 01/2018 - 02/2015
4	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 05/2021 - 12/2012
4	N- (4- cyanophenylmethyl)- 4- (2- diphenyl)- 1- piperazinehexanamideIBA 10/2017 - 01/2014
3	Bombesin Receptors (Bombesin Receptor)IBA 01/2018 - 02/2015
2	Biological ProductsIBA 02/2022 - 01/2022
2	Neuroprotective AgentsIBA 01/2022 - 01/2014
2	Amyloid (Amyloid Fibrils)IBA 12/2021 - 07/2016
2	Proteins (Proteins, Gene)FDA Link 06/2021 - 04/2014
2	Antidepressive Agents (Antidepressants)IBA 10/2018 - 10/2013
1	AntioxidantsIBA 02/2022
1	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 02/2022
1	lipoxin A4IBA 01/2022
1	Amyloid beta-PeptidesIBA 12/2021
1	Cyclin-Dependent Kinase 5IBA 05/2021
1	CytokinesIBA 01/2021
1	Histones (Histone)IBA 01/2021
1	Co-Repressor ProteinsIBA 01/2021
1	InflammasomesIBA 01/2021
1	Pharmaceutical PreparationsIBA 08/2020
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 01/2020
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2020
1	LipidsIBA 01/2020
1	LipoxinsIBA 01/2020
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2019
1	4- (2- methylthiophenyl)- N- (1,2,3,4- tetrahydronaphthalen- 1- yl)- 1- piperazinehexanamideIBA 01/2018
1	Capsaicin (Zostrix)FDA Link 01/2018
1	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 01/2018
1	IntegrinsIBA 01/2018
1	SB 269970IBA 01/2018
1	Vasopressins (Vasopressin)IBA 11/2017
1	LipopolysaccharidesIBA 11/2017
1	Oxytocin (Pitocin)FDA LinkGeneric 11/2017
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2017
1	Cyclic NucleotidesIBA 10/2017
1	BombesinIBA 01/2017
1	Carbon-11IBA 07/2016
1	Formaldehyde (Formol)FDA Link 05/2016
1	Analgesics (Analgesic Drugs)IBA 05/2016
1	Ergotamine (Ergotamine Tartrate)FDA LinkGeneric 04/2015
1	SB 399885IBA 04/2015
1	Tyrosine (L-Tyrosine)FDA Link 02/2015
1	bombesin receptor subtype 3IBA 02/2015
1	N-Methylaspartate (NMDA)IBA 01/2014
1	Amino Acids FDA Link 01/2014
1	Morphine (MS Contin)FDA LinkGeneric 01/2014

Therapy/Procedure

4	Therapeutics 06/2021 - 04/2014
1	Drug Therapy (Chemotherapy) 11/2017